Specialized Pro‑Resolving Mediators (SPMs) & Omega‑3

What SPMs are

SPMs are signaling molecules formed from long‑chain omega‑3 fatty acids.
Examples include resolvins, protectins, and maresins.
They are studied for their roles in the resolution phase of normal inflammatory processes.

How SPMs relate to EPA and DHA

EPA and DHA can be enzymatically converted into SPM precursors and SPMs in humans.
Reports measured changes in SPM pathway markers after EPA/DHA intake under controlled conditions.

Specialized pro‑resolving mediators (SPMs) from omega‑3 EPA and DHA: resolvins, protectins, and maresins — SPMs derived from omega‑3 EPA and DHA: resolvins, protectins and maresins.

Measurement notes

Specialized pro‑resolving mediators and precursors are often measured with liquid chromatography tandem mass spectrometry (LC‑MS/MS) in plasma or serum.
Results can vary with dose, timing, and biological matrix.
Reports distinguish between precursors and bioactive mediators.

Related sections

Nutrients (see eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA))

Last Updated: 3 September 2025