Thorne Stress B-Complex
vs
Metagenics SeroSyn
Supplement Comparison

  • Vitamin B12 (Cobalamin): Metagenics SeroSyn has 2.5× more
  • Vitamin B9 (Folate): Metagenics SeroSyn has 66% more
  • Vitamin B6 (Pyridoxine): Thorne Stress B-Complex has 2.8× more
  • The image below shows:
    • Side-by-side charts with label nutrient amounts, per serving
    • Nutrient forms as listed on the label
    • 21 nutrients compared
Bar chart: per-serving label amounts and listed forms for Thorne Stress B-Complex vs Metagenics SeroSyn.

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Frequently asked questions

Which active ingredients does Thorne Stress B-Complex have?

  • Vitamin B1 (Thiamin) appears as Thiamin HCl
  • Vitamin B2 (Riboflavin) appears as Riboflavin 5-Phosphate Sodium
  • Vitamin B2 (Riboflavin) appears as Riboflavin
  • Vitamin B3 (Niacin) appears as Niacinamide
  • Vitamin B6 (Pyridoxine) appears as Pyridoxal 5-Phosphate
  • Vitamin B6 (Pyridoxine) appears as Pyridoxine HCl
  • Vitamin B9 (Folate) appears as L-5-Methyltetrahydrofolate
  • Vitamin B12 (Cobalamin) appears as Methylcobalamin
  • Vitamin B7 (Biotin)
  • Vitamin B5 (Pantothenic Acid) appears as Calcium Pantothenate

Which active ingredients does Metagenics SeroSyn have?

  • Vitamin B6 (Pyridoxine) appears as Pyridoxine HCl
  • Vitamin B9 (Folate) appears as Calcium-L-5-methyltetrahydrofolate
  • Vitamin B12 (Cobalamin) appears as Methylcobalamin
  • 5-Hydroxytryptophan
  • Asian Ginseng Extract appears as Asian Ginseng (Panax ginseng) Root Extract standardized to 8% ginsenosides
  • L-Theanine
  • Chinese Skullcap (Scutellaria baicalensis) appears as Chinese Skullcap (Scutellaria baicalensis) Root Extract standardized to 30% flavones

Which categories do Thorne Stress B-Complex and Metagenics SeroSyn belong to?

  • Single Vitamin
  • Single Mineral

What health concerns do Thorne Stress B-Complex and Metagenics SeroSyn address?

  • Brain, Focus & Cognitive Function
  • Energy & Metabolism
  • General Health
  • Stress Management
  • Mood Support

Which product has a higher amount of Vitamin B12 (Cobalamin) per serving?

  • Metagenics SeroSyn has the highest total amount of Vitamin B12 (Cobalamin): 250 mcg per serving

Which product has a higher amount of Vitamin B9 (Folate) per serving?

  • Metagenics SeroSyn has the highest total amount of Vitamin B9 (Folate): 555 mcg DFE per serving

Which product has a higher amount of Vitamin B6 (Pyridoxine) per serving?

  • Thorne Stress B-Complex has the highest total amount of Vitamin B6 (Pyridoxine): 25 mg per serving

How do the serving sizes compare between the two supplements?

  • Serving size:
    • Thorne Stress B-Complex: 1 capsule
    • Metagenics SeroSyn: 1 capsule
  • Vitamin B1 (Thiamin)
    • This supplement has 50 mg
    • Recommended Dietary Allowance in men: 1.2 mg
    • Recommended Dietary Allowance in women: 1.1 mg
    • Tolerable Upper Intake Level: Not established
  • Vitamin B2 (Riboflavin)
    • This supplement has 28.6 mg
    • Recommended Dietary Allowance in men: 1.3 mg
    • Recommended Dietary Allowance in women: 1.1 mg
    • Tolerable Upper Intake Level: Not established
  • Vitamin B3 (Niacin)
    • This supplement has 80 mg
    • Recommended Dietary Allowance in men: 16 mg
    • Recommended Dietary Allowance in women: 14 mg
    • Tolerable Upper Intake Level: 35 mg
  • Vitamin B6 (Pyridoxine)
    • This supplement has 28.4 mg
    • Recommended Dietary Allowance in men: 1.3 mg
    • Recommended Dietary Allowance in women: 1.3 mg
    • Tolerable Upper Intake Level: 100 mg
  • Vitamin B9 (Folate)
    • This supplement has 334 mcg DFE
    • Recommended Dietary Allowance in men: 400 mcg DFE
    • Recommended Dietary Allowance in women: 400 mcg DFE
    • Tolerable Upper Intake Level: 1000 mcg DFE
  • Vitamin B12 (Cobalamin)
    • This supplement has 100 mcg
    • Recommended Dietary Allowance in men: 2.4 mcg
    • Recommended Dietary Allowance in women: 2.4 mcg
    • Tolerable Upper Intake Level: Not established
  • Vitamin B6 (Pyridoxine)
    • This supplement has 10 mg
    • Recommended Dietary Allowance in men: 1.3 mg
    • Recommended Dietary Allowance in women: 1.3 mg
    • Tolerable Upper Intake Level: 100 mg
  • Vitamin B9 (Folate)
    • This supplement has 555 mcg DFE
    • Recommended Dietary Allowance in men: 400 mcg DFE
    • Recommended Dietary Allowance in women: 400 mcg DFE
    • Tolerable Upper Intake Level: 1000 mcg DFE
  • Vitamin B12 (Cobalamin)
    • This supplement has 250 mcg
    • Recommended Dietary Allowance in men: 2.4 mcg
    • Recommended Dietary Allowance in women: 2.4 mcg
    • Tolerable Upper Intake Level: Not established

Last updated: February 16, 2026

  • Sources & Methodology: Nutrient data and forms are taken directly from Supplement Facts labels. Reviewed and standardized by the VIOscan Research Team. Learn more on the Methodology page.
  • We show the Recommended Dietary Allowance (RDA) when available. If no RDA exists, we show the Adequate Intake (AI). Tolerable Upper Intake Levels (UL) are used for upper limits. Unless otherwise noted, RDAs shown correspond to healthy adults aged 19–50 years and are sex-specific. Separate values exist for 51–70 years and >70 years, and pregnancy and lactation are excluded. All values come from the Dietary Reference Intakes (DRIs) published by the National Academies of Sciences, Engineering, and Medicine (NASEM), Food and Nutrition Board (FNB).
  • Transparency: We’re funded by our users. We don’t have sponsors or affiliate links, and we don’t sell supplements.
  • Editorial standards: we provide independent, impartial and objective data analysis.
  • This analysis is for educational purposes only. It is not a substitute for medical advice.
  • Questions? Read our Frequently Asked Questions or contact us, we’re here to help.
  • See an error? Report it through our Contact page.
  • Author: VIOscan Research Team