Thorne Methyl-Guard Plus
vs
21st Century B-Complex Plus Vitamin C
Supplement Comparison

  • Vitamin B6 (Pyridoxine): Thorne Methyl-Guard Plus has 9.0× more
  • Vitamin B2 (Riboflavin): Thorne Methyl-Guard Plus has 6.3× more
  • The image below shows:
    • Side-by-side charts with label nutrient amounts, per serving
    • Nutrient forms as listed on the label
    • 18 nutrients compared
Bar chart: per-serving label amounts and listed forms for Thorne Methyl-Guard Plus vs 21st Century B-Complex Plus Vitamin C.

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Frequently asked questions

Which active ingredients does Thorne Methyl-Guard Plus have?

  • Vitamin B2 (Riboflavin) appears as Riboflavin 5-Phosphate Sodium
  • Vitamin B6 (Pyridoxine) appears as Pyridoxal 5-Phosphate
  • Vitamin B9 (Folate) appears as L-5-Methyltetrahydrofolate
  • Vitamin B12 (Cobalamin) appears as Methylcobalamin

Which active ingredients does 21st Century B-Complex Plus Vitamin C have?

  • Vitamin C appears as Ascorbic Acid
  • Vitamin B1 (Thiamin) appears as Thiamin Mononitrate
  • Vitamin B2 (Riboflavin) appears as Riboflavin
  • Vitamin B3 (Niacin) appears as Niacinamide
  • Vitamin B6 (Pyridoxine) appears as Pyridoxine HCl
  • Vitamin B5 (Pantothenic Acid) appears as D-Calcium Pantothenate
  • Calcium appears as Calcium Carbonate and Dicalcium Phosphate

Which categories do Thorne Methyl-Guard Plus and 21st Century B-Complex Plus Vitamin C belong to?

  • Methylation Formula
  • B-Complex Formula

What health concerns do Thorne Methyl-Guard Plus and 21st Century B-Complex Plus Vitamin C address?

  • Brain, Focus & Cognitive Function
  • Heart & Cardiovascular Health
  • Methylation Support
  • Mood Support
  • Antioxidant Support
  • Energy & Metabolism
  • General Health
  • Neurological Support

Which product has a higher amount of Vitamin B6 (Pyridoxine) per serving?

  • Thorne Methyl-Guard Plus has the highest total amount of Vitamin B6 (Pyridoxine): 45 mg per serving

Which product has a higher amount of Vitamin B2 (Riboflavin) per serving?

  • Thorne Methyl-Guard Plus has the highest total amount of Vitamin B2 (Riboflavin): 90 mg per serving

How do the serving sizes compare between the two supplements?

  • Serving size:
    • Thorne Methyl-Guard Plus: 3 capsules
    • 21st Century B-Complex Plus Vitamin C: 1 tablet
  • Vitamin B2 (Riboflavin)
    • This supplement has 90 mg
    • Recommended Dietary Allowance in men: 1.3 mg
    • Recommended Dietary Allowance in women: 1.1 mg
    • Tolerable Upper Intake Level: Not established
  • Vitamin B6 (Pyridoxine)
    • This supplement has 45 mg
    • Recommended Dietary Allowance in men: 1.3 mg
    • Recommended Dietary Allowance in women: 1.3 mg
    • Tolerable Upper Intake Level: 100 mg
  • Vitamin B9 (Folate)
    • This supplement has 5 mcg DFE
    • Recommended Dietary Allowance in men: 400 mcg DFE
    • Recommended Dietary Allowance in women: 400 mcg DFE
    • Tolerable Upper Intake Level: 1000 mcg DFE
  • Vitamin B12 (Cobalamin)
    • This supplement has 3000 mcg
    • Recommended Dietary Allowance in men: 2.4 mcg
    • Recommended Dietary Allowance in women: 2.4 mcg
    • Tolerable Upper Intake Level: Not established
  • Vitamin C
    • This supplement has 300 mg
    • Recommended Dietary Allowance in men: 90 mg
    • Recommended Dietary Allowance in women: 75 mg
    • Tolerable Upper Intake Level: 2000 mg
  • Vitamin B1 (Thiamin)
    • This supplement has 15 mg
    • Recommended Dietary Allowance in men: 1.2 mg
    • Recommended Dietary Allowance in women: 1.1 mg
    • Tolerable Upper Intake Level: Not established
  • Vitamin B2 (Riboflavin)
    • This supplement has 14.3 mg
    • Recommended Dietary Allowance in men: 1.3 mg
    • Recommended Dietary Allowance in women: 1.1 mg
    • Tolerable Upper Intake Level: Not established
  • Vitamin B3 (Niacin)
    • This supplement has 50 mg
    • Recommended Dietary Allowance in men: 16 mg
    • Recommended Dietary Allowance in women: 14 mg
    • Tolerable Upper Intake Level: 35 mg
  • Vitamin B6 (Pyridoxine)
    • This supplement has 5 mg
    • Recommended Dietary Allowance in men: 1.3 mg
    • Recommended Dietary Allowance in women: 1.3 mg
    • Tolerable Upper Intake Level: 100 mg
  • Vitamin B5 (Pantothenic Acid)
    • This supplement has 10 mg
    • Adequate Intake in men: 5 mg
    • Adequate Intake in women: 5 mg
    • Tolerable Upper Intake Level: Not established

Last updated: February 3, 2026

  • Sources & Methodology: Nutrient data and forms are taken directly from Supplement Facts labels. Reviewed and standardized by the VIOscan Research Team. Learn more on the Methodology page.
  • We show the Recommended Dietary Allowance (RDA) when available. If no RDA exists, we show the Adequate Intake (AI). Tolerable Upper Intake Levels (UL) are used for upper limits. Unless otherwise noted, RDAs shown correspond to healthy adults aged 19–50 years and are sex-specific. Separate values exist for 51–70 years and >70 years, and pregnancy and lactation are excluded. All values come from the Dietary Reference Intakes (DRIs) published by the National Academies of Sciences, Engineering, and Medicine (NASEM), Food and Nutrition Board (FNB).
  • Transparency: We’re funded by our users. We don’t have sponsors or affiliate links, and we don’t sell supplements.
  • Editorial standards: we provide independent, impartial and objective data analysis.
  • This analysis is for educational purposes only. It is not a substitute for medical advice.
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  • Author: VIOscan Research Team