Thorne Advanced Bone Support
vs
21st Century Vitamin B-12 5000 mcg
Supplement Comparison

  • Vitamin B12 (Cobalamin): 21st Century Vitamin B-12 5000 mcg has 100× more
  • The image below shows:
    • Side-by-side charts with label nutrient amounts, per serving
    • Nutrient forms as listed on the label
    • 11 nutrients compared
Bar chart: per-serving label amounts and listed forms for Thorne Advanced Bone Support vs 21st Century Vitamin B-12 5000 mcg.

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Frequently asked questions

Which active ingredients does Thorne Advanced Bone Support have?

  • Vitamin D appears as Cholecalciferol (D3)
  • Vitamin B6 (Pyridoxine) appears as Pyridoxal 5-Phosphate
  • Vitamin B9 (Folate) appears as L-5-Methyltetrahydrofolate
  • Vitamin B12 (Cobalamin) appears as Methylcobalamin
  • Calcium
  • Magnesium
  • Boron

Which active ingredients does 21st Century Vitamin B-12 5000 mcg have?

  • Vitamin B12 (Cobalamin) appears as Cyanocobalamin

Which categories do Thorne Advanced Bone Support and 21st Century Vitamin B-12 5000 mcg belong to?

  • Single Mineral
  • Single Vitamin

What health concerns do Thorne Advanced Bone Support and 21st Century Vitamin B-12 5000 mcg address?

  • Healthy Aging & Longevity
  • Hormonal Balance
  • Joint & Bone Health
  • Women's Health
  • General Health

Which product has a higher amount of Vitamin B12 (Cobalamin) per serving?

  • 21st Century Vitamin B-12 5000 mcg has the highest total amount of Vitamin B12 (Cobalamin): 5000 mcg per serving

How do the serving sizes compare between the two supplements?

  • Serving size:
    • Thorne Advanced Bone Support: 2 capsules
    • 21st Century Vitamin B-12 5000 mcg: 1 tablet
  • Vitamin D
    • This supplement has 1000 IU
    • Recommended Dietary Allowance in men: 600 IU
    • Recommended Dietary Allowance in women: 600 IU
    • Tolerable Upper Intake Level: 4000 IU
  • Vitamin B6 (Pyridoxine)
    • This supplement has 20 mg
    • Recommended Dietary Allowance in men: 1.3 mg
    • Recommended Dietary Allowance in women: 1.3 mg
    • Tolerable Upper Intake Level: 100 mg
  • Vitamin B9 (Folate)
    • This supplement has 166.6 mcg DFE
    • Recommended Dietary Allowance in men: 400 mcg DFE
    • Recommended Dietary Allowance in women: 400 mcg DFE
    • Tolerable Upper Intake Level: 1000 mcg DFE
  • Vitamin B12 (Cobalamin)
    • This supplement has 50 mcg
    • Recommended Dietary Allowance in men: 2.4 mcg
    • Recommended Dietary Allowance in women: 2.4 mcg
    • Tolerable Upper Intake Level: Not established
  • Calcium
    • This supplement has 300 mg
    • Recommended Dietary Allowance in men: 1000 mg
    • Recommended Dietary Allowance in women: 1000 mg
    • Tolerable Upper Intake Level: 2500 mg
  • Vitamin B12 (Cobalamin)
    • This supplement has 5000 mcg
    • Recommended Dietary Allowance in men: 2.4 mcg
    • Recommended Dietary Allowance in women: 2.4 mcg
    • Tolerable Upper Intake Level: Not established

Last updated: February 4, 2026

  • Sources & Methodology: Nutrient data and forms are taken directly from Supplement Facts labels. Reviewed and standardized by the VIOscan Research Team. Learn more on the Methodology page.
  • We show the Recommended Dietary Allowance (RDA) when available. If no RDA exists, we show the Adequate Intake (AI). Tolerable Upper Intake Levels (UL) are used for upper limits. Unless otherwise noted, RDAs shown correspond to healthy adults aged 19–50 years and are sex-specific. Separate values exist for 51–70 years and >70 years, and pregnancy and lactation are excluded. All values come from the Dietary Reference Intakes (DRIs) published by the National Academies of Sciences, Engineering, and Medicine (NASEM), Food and Nutrition Board (FNB).
  • Transparency: We’re funded by our users. We don’t have sponsors or affiliate links, and we don’t sell supplements.
  • Editorial standards: we provide independent, impartial and objective data analysis.
  • This analysis is for educational purposes only. It is not a substitute for medical advice.
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  • Author: VIOscan Research Team