Metagenics MethylCare
vs
Metagenics Fem EstroPlex
Supplement Comparison

  • Vitamin B6 (Pyridoxine): Metagenics Fem EstroPlex has 2.0× more
  • The image below shows:
    • Side-by-side charts with label nutrient amounts, per serving
    • Nutrient forms as listed on the label
    • 24 nutrients compared
Bar chart: per-serving label amounts and listed forms for Metagenics MethylCare vs Metagenics Fem EstroPlex.

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Frequently asked questions

Which active ingredients does Metagenics MethylCare have?

  • Vitamin B2 (Riboflavin) appears as Riboflavin
  • Vitamin B6 (Pyridoxine) appears as Pyridoxine HCl
  • Vitamin B9 (Folate) appears as Calcium L-5-Methyltetrahydrofolate
  • Vitamin B12 (Cobalamin) appears as Methylcobalamin
  • Zinc appears as Zinc Citrate
  • Manganese appears as Manganese Citrate
  • Molybdenum appears as Molybdenum Glycinate
  • Betaine Hydrochloride
  • N-Acetyl-L-Cysteine (NAC)

Which active ingredients does Metagenics Fem EstroPlex have?

  • Vitamin C appears as Ascorbic Acid
  • Vitamin E appears as d-Alpha Tocopheryl Succinate
  • Vitamin B6 (Pyridoxine) appears as Pyridoxine HCl
  • Vitamin B5 (Pantothenic Acid) appears as D-Calcium Pantothenate
  • Rutin
  • Blend appears as Proprietary Herbal Extract Blend (Dandelion Chasteberry Valerian Motherwort Stinging Nettle)

Which categories do Metagenics MethylCare and Metagenics Fem EstroPlex belong to?

  • Methylation Formula
  • Hormone Support Formula

What health concerns do Metagenics MethylCare and Metagenics Fem EstroPlex address?

  • Energy & Metabolism
  • General Health
  • Liver & Detox Support
  • Methylation Support
  • Women's Health

Which product has a higher amount of Vitamin B6 (Pyridoxine) per serving?

  • Metagenics Fem EstroPlex has the highest total amount of Vitamin B6 (Pyridoxine): 50 mg per serving

How do the serving sizes compare between the two supplements?

  • Serving size:
    • Metagenics MethylCare: 2 capsules
    • Metagenics Fem EstroPlex: 3 tablets
  • Vitamin B2 (Riboflavin)
    • This supplement has 1.6 mg
    • Recommended Dietary Allowance in men: 1.3 mg
    • Recommended Dietary Allowance in women: 1.1 mg
    • Tolerable Upper Intake Level: Not established
  • Vitamin B6 (Pyridoxine)
    • This supplement has 25 mg
    • Recommended Dietary Allowance in men: 1.3 mg
    • Recommended Dietary Allowance in women: 1.3 mg
    • Tolerable Upper Intake Level: 100 mg
  • Vitamin B9 (Folate)
    • This supplement has 1330 mcg DFE
    • Recommended Dietary Allowance in men: 400 mcg DFE
    • Recommended Dietary Allowance in women: 400 mcg DFE
    • Tolerable Upper Intake Level: 1000 mcg DFE
  • Vitamin B12 (Cobalamin)
    • This supplement has 1000 mcg
    • Recommended Dietary Allowance in men: 2.4 mcg
    • Recommended Dietary Allowance in women: 2.4 mcg
    • Tolerable Upper Intake Level: Not established
  • Zinc
    • This supplement has 1.5 mg
    • Recommended Dietary Allowance in men: 11 mg
    • Recommended Dietary Allowance in women: 8 mg
    • Tolerable Upper Intake Level: 40 mg
  • Manganese
    • This supplement has 0.4 mg
    • Adequate Intake in men: 2.3 mg
    • Adequate Intake in women: 1.8 mg
    • Tolerable Upper Intake Level: 11 mg
  • Vitamin C
    • This supplement has 300 mg
    • Recommended Dietary Allowance in men: 90 mg
    • Recommended Dietary Allowance in women: 75 mg
    • Tolerable Upper Intake Level: 2000 mg
  • Vitamin E
    • This supplement has 67 mg
    • Recommended Dietary Allowance in men: 15 mg
    • Recommended Dietary Allowance in women: 15 mg
    • Tolerable Upper Intake Level: 1000 mg
  • Vitamin B6 (Pyridoxine)
    • This supplement has 50 mg
    • Recommended Dietary Allowance in men: 1.3 mg
    • Recommended Dietary Allowance in women: 1.3 mg
    • Tolerable Upper Intake Level: 100 mg
  • Vitamin B5 (Pantothenic Acid)
    • This supplement has 300 mg
    • Adequate Intake in men: 5 mg
    • Adequate Intake in women: 5 mg
    • Tolerable Upper Intake Level: Not established

Last updated: February 9, 2026

  • Sources & Methodology: Nutrient data and forms are taken directly from Supplement Facts labels. Reviewed and standardized by the VIOscan Research Team. Learn more on the Methodology page.
  • We show the Recommended Dietary Allowance (RDA) when available. If no RDA exists, we show the Adequate Intake (AI). Tolerable Upper Intake Levels (UL) are used for upper limits. Unless otherwise noted, RDAs shown correspond to healthy adults aged 19–50 years and are sex-specific. Separate values exist for 51–70 years and >70 years, and pregnancy and lactation are excluded. All values come from the Dietary Reference Intakes (DRIs) published by the National Academies of Sciences, Engineering, and Medicine (NASEM), Food and Nutrition Board (FNB).
  • Transparency: We’re funded by our users. We don’t have sponsors or affiliate links, and we don’t sell supplements.
  • Editorial standards: we provide independent, impartial and objective data analysis.
  • This analysis is for educational purposes only. It is not a substitute for medical advice.
  • Questions? Read our Frequently Asked Questions or contact us, we’re here to help.
  • See an error? Report it through our Contact page.
  • Author: VIOscan Research Team