Douglas Laboratories Methyl Folate 1,000 mcg Metafolin
vs
Metagenics SeroSyn
Supplement Comparison

  • Vitamin B9 (Folate): Douglas Laboratories Methyl Folate 1,000 mcg Metafolin has 3.0× more
  • The image below shows:
    • Side-by-side charts with label nutrient amounts, per serving
    • Nutrient forms as listed on the label
    • 12 nutrients compared
Bar chart: per-serving label amounts and listed forms for Douglas Laboratories Methyl Folate 1,000 mcg Metafolin vs Metagenics SeroSyn.

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Frequently asked questions

Which active ingredients does Douglas Laboratories Methyl Folate 1,000 mcg Metafolin have?

  • Vitamin B9 (Folate) appears as Metafolin L-5-MTHF

Which active ingredients does Metagenics SeroSyn have?

  • Vitamin B6 (Pyridoxine) appears as Pyridoxine HCl
  • Vitamin B9 (Folate) appears as Calcium-L-5-methyltetrahydrofolate
  • Vitamin B12 (Cobalamin) appears as Methylcobalamin
  • 5-Hydroxytryptophan
  • Asian Ginseng Extract appears as Asian Ginseng (Panax ginseng) Root Extract standardized to 8% ginsenosides
  • L-Theanine
  • Chinese Skullcap (Scutellaria baicalensis) appears as Chinese Skullcap (Scutellaria baicalensis) Root Extract standardized to 30% flavones

Which categories do Douglas Laboratories Methyl Folate 1,000 mcg Metafolin and Metagenics SeroSyn belong to?

  • Single Vitamin
  • Single Mineral

What health concerns do Douglas Laboratories Methyl Folate 1,000 mcg Metafolin and Metagenics SeroSyn address?

  • Immune System Support
  • Methylation Support
  • Pregnancy Support
  • Mood Support
  • Stress Management

Which product has a higher amount of Vitamin B9 (Folate) per serving?

  • Douglas Laboratories Methyl Folate 1,000 mcg Metafolin has the highest total amount of Vitamin B9 (Folate): 1667 mcg DFE per serving

How do the serving sizes compare between the two supplements?

  • Serving size:
    • Douglas Laboratories Methyl Folate 1,000 mcg Metafolin: 1 tablet
    • Metagenics SeroSyn: 1 capsule
  • Vitamin B9 (Folate)
    • This supplement has 1667 mcg DFE
    • Recommended Dietary Allowance in men: 400 mcg DFE
    • Recommended Dietary Allowance in women: 400 mcg DFE
    • Tolerable Upper Intake Level: 1000 mcg DFE
  • Vitamin B6 (Pyridoxine)
    • This supplement has 10 mg
    • Recommended Dietary Allowance in men: 1.3 mg
    • Recommended Dietary Allowance in women: 1.3 mg
    • Tolerable Upper Intake Level: 100 mg
  • Vitamin B9 (Folate)
    • This supplement has 555 mcg DFE
    • Recommended Dietary Allowance in men: 400 mcg DFE
    • Recommended Dietary Allowance in women: 400 mcg DFE
    • Tolerable Upper Intake Level: 1000 mcg DFE
  • Vitamin B12 (Cobalamin)
    • This supplement has 250 mcg
    • Recommended Dietary Allowance in men: 2.4 mcg
    • Recommended Dietary Allowance in women: 2.4 mcg
    • Tolerable Upper Intake Level: Not established

Last updated: February 9, 2026

  • Sources & Methodology: Nutrient data and forms are taken directly from Supplement Facts labels. Reviewed and standardized by the VIOscan Research Team. Learn more on the Methodology page.
  • We show the Recommended Dietary Allowance (RDA) when available. If no RDA exists, we show the Adequate Intake (AI). Tolerable Upper Intake Levels (UL) are used for upper limits. Unless otherwise noted, RDAs shown correspond to healthy adults aged 19–50 years and are sex-specific. Separate values exist for 51–70 years and >70 years, and pregnancy and lactation are excluded. All values come from the Dietary Reference Intakes (DRIs) published by the National Academies of Sciences, Engineering, and Medicine (NASEM), Food and Nutrition Board (FNB).
  • Transparency: We’re funded by our users. We don’t have sponsors or affiliate links, and we don’t sell supplements.
  • Editorial standards: we provide independent, impartial and objective data analysis.
  • This analysis is for educational purposes only. It is not a substitute for medical advice.
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  • Author: VIOscan Research Team