21st Century Vitamin B-12 1000 mcg
vs
Metagenics Bone Builder Plus
Supplement Comparison

  • Calcium: Metagenics Bone Builder Plus has 4.2× more
  • The image below shows:
    • Side-by-side charts with label nutrient amounts, per serving
    • Nutrient forms as listed on the label
    • 9 nutrients compared
Bar chart: per-serving label amounts and listed forms for 21st Century Vitamin B-12 1000 mcg vs Metagenics Bone Builder Plus.

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Frequently asked questions

Which active ingredients does 21st Century Vitamin B-12 1000 mcg have?

  • Vitamin B12 (Cobalamin) appears as Cyanocobalamin
  • Calcium appears as Calcium Carbonate

Which active ingredients does Metagenics Bone Builder Plus have?

  • Vitamin D appears as Cholecalciferol (D3)
  • Calcium appears as Calcium from Microcrystalline Hydroxyapatite (bovine)
  • Phosphorus appears as Phosphorus as Microcrystalline Hydroxyapatite
  • Microcrystalline Hydroxyapatite Concentrate (MCHC)

Which categories do 21st Century Vitamin B-12 1000 mcg and Metagenics Bone Builder Plus belong to?

  • Single Vitamin
  • Joint Formula

What health concerns do 21st Century Vitamin B-12 1000 mcg and Metagenics Bone Builder Plus address?

  • General Health
  • Joint & Bone Health

Which product has a higher amount of Calcium per serving?

  • Metagenics Bone Builder Plus has the highest total amount of Calcium: 420 mg per serving

How do the serving sizes compare between the two supplements?

  • Serving size:
    • 21st Century Vitamin B-12 1000 mcg: 1 tablet
    • Metagenics Bone Builder Plus: 2 capsules
  • Vitamin B12 (Cobalamin)
    • This supplement has 1000 mcg
    • Recommended Dietary Allowance in men: 2.4 mcg
    • Recommended Dietary Allowance in women: 2.4 mcg
    • Tolerable Upper Intake Level: Not established
  • Calcium
    • This supplement has 100 mg
    • Recommended Dietary Allowance in men: 1000 mg
    • Recommended Dietary Allowance in women: 1000 mg
    • Tolerable Upper Intake Level: 2500 mg
  • Vitamin D
    • This supplement has 2000 IU
    • Recommended Dietary Allowance in men: 600 IU
    • Recommended Dietary Allowance in women: 600 IU
    • Tolerable Upper Intake Level: 4000 IU
  • Calcium
    • This supplement has 420 mg
    • Recommended Dietary Allowance in men: 1000 mg
    • Recommended Dietary Allowance in women: 1000 mg
    • Tolerable Upper Intake Level: 2500 mg
  • Phosphorus
    • This supplement has 160 mg
    • Recommended Dietary Allowance in men: 700 mg
    • Recommended Dietary Allowance in women: 700 mg
    • Tolerable Upper Intake Level: 4000 mg

Last updated: February 5, 2026

  • Sources & Methodology: Nutrient data and forms are taken directly from Supplement Facts labels. Reviewed and standardized by the VIOscan Research Team. Learn more on the Methodology page.
  • We show the Recommended Dietary Allowance (RDA) when available. If no RDA exists, we show the Adequate Intake (AI). Tolerable Upper Intake Levels (UL) are used for upper limits. Unless otherwise noted, RDAs shown correspond to healthy adults aged 19–50 years and are sex-specific. Separate values exist for 51–70 years and >70 years, and pregnancy and lactation are excluded. All values come from the Dietary Reference Intakes (DRIs) published by the National Academies of Sciences, Engineering, and Medicine (NASEM), Food and Nutrition Board (FNB).
  • Transparency: We’re funded by our users. We don’t have sponsors or affiliate links, and we don’t sell supplements.
  • Editorial standards: we provide independent, impartial and objective data analysis.
  • This analysis is for educational purposes only. It is not a substitute for medical advice.
  • Questions? Read our Frequently Asked Questions or contact us, we’re here to help.
  • See an error? Report it through our Contact page.
  • Author: VIOscan Research Team